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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

The T-box transcription factor T-bet is important for the differentiation of naive CD4(+) T helper cells (Th cells) into the Th1 phenotype. Much is known about T-bet’s role as a transcriptional activator, but less is known about the mechanisms by which T-bet functionally represses alternative Th cel...

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Detalles Bibliográficos
Autores principales: Oestreich, Kenneth J., Huang, Albert C., Weinmann, Amy S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092354/
https://www.ncbi.nlm.nih.gov/pubmed/21518797
http://dx.doi.org/10.1084/jem.20102144