PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

PRDM9 has recently been identified as a likely trans-regulator of meiotic recombination hot spots in humans and mice1-3. The protein contains a zinc finger array that in humans can recognise a short sequence motif associated with hot spots4, with binding to this motif possibly triggering hot-spot ac...

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Detalles Bibliográficos
Autores principales: Berg, Ingrid L., Neumann, Rita, Lam, Kwan-Wood G., Sarbajna, Shriparna, Odenthal-Hesse, Linda, May, Celia A., Jeffreys, Alec J.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092422/
https://www.ncbi.nlm.nih.gov/pubmed/20818382
http://dx.doi.org/10.1038/ng.658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092422/
https://www.ncbi.nlm.nih.gov/pubmed/20818382
http://dx.doi.org/10.1038/ng.658

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