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PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

PRDM9 has recently been identified as a likely trans-regulator of meiotic recombination hot spots in humans and mice1-3. The protein contains a zinc finger array that in humans can recognise a short sequence motif associated with hot spots4, with binding to this motif possibly triggering hot-spot ac...

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Detalles Bibliográficos
Autores principales:	Berg, Ingrid L., Neumann, Rita, Lam, Kwan-Wood G., Sarbajna, Shriparna, Odenthal-Hesse, Linda, May, Celia A., Jeffreys, Alec J.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092422/ https://www.ncbi.nlm.nih.gov/pubmed/20818382 http://dx.doi.org/10.1038/ng.658

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