(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli

[Image: see text] 8,5′-Cyclopurines, making up an important class of ionizing radiation-induced tandem DNA damage, are repaired only by nucleotide excision repair (NER). They accumulate in NER-impaired cells, as in Cockayne syndrome group B and certain Xeroderma Pigmentosum patients. A plasmid conta...

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Detalles Bibliográficos
Autores principales: Jasti, Vijay P., Das, Rajat S., Hilton, Benjamin A., Weerasooriya, Savithri, Zou, Yue, Basu, Ashis K.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092667/
https://www.ncbi.nlm.nih.gov/pubmed/21491964
http://dx.doi.org/10.1021/bi2004944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092667/
https://www.ncbi.nlm.nih.gov/pubmed/21491964
http://dx.doi.org/10.1021/bi2004944

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