MCP-1 Upregulates Amylin Expression in Murine Pancreatic β Cells through ERK/JNK-AP1 and NF-κB Related Signaling Pathways Independent of CCR2

BACKGROUND: Amylin is the most abundant component of islet amyloid implicated in the development of type 2 diabetes. Plasma amylin levels are elevated in individuals with obesity and insulin resistance. Monocyte chemoattractant protein-1 (MCP-1, CCL2) is involved in insulin resistance of obesity and...

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Detalles Bibliográficos
Autores principales: Cai, Kun, Qi, Dongfei, Hou, Xinwei, Wang, Oumei, Chen, Juan, Deng, Bo, Qian, Lihua, Liu, Xiaolong, Le, Yingying
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092759/
https://www.ncbi.nlm.nih.gov/pubmed/21589925
http://dx.doi.org/10.1371/journal.pone.0019559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092759/
https://www.ncbi.nlm.nih.gov/pubmed/21589925
http://dx.doi.org/10.1371/journal.pone.0019559

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