Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice

 Peroxisomal testis-specific 1 gene (Pxt1) is the only male germ cell–specific gene that encodes a peroxisomal protein known to date. To elucidate the role of Pxt1 in spermatogenesis, we generated transgenic mice expressing a c-MYC-PXT1 fusion protein under the control of the PGK2 promoter. Overexpr...

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Detalles Bibliográficos
Autores principales: Kaczmarek, Karina, Studencka, Maja, Meinhardt, Andreas, Wieczerzak, Krzysztof, Thoms, Sven, Engel, Wolfgang, Grzmil, Pawel
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093327/
https://www.ncbi.nlm.nih.gov/pubmed/21460186
http://dx.doi.org/10.1091/mbc.E09-12-0993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093327/
https://www.ncbi.nlm.nih.gov/pubmed/21460186
http://dx.doi.org/10.1091/mbc.E09-12-0993

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