Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP–treated PC12D cells

The second messenger cAMP plays a pivotal role in neurite/axon growth and guidance, but its downstream pathways leading to the regulation of Rho GTPases, centrally implicated in neuronal morphogenesis, remain elusive. We examined spatiotemporal changes in Rac1 and Cdc42 activity and phosphatidylinos...

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Detalles Bibliográficos
Autores principales: Goto, Akihiro, Hoshino, Mikio, Matsuda, Michiyuki, Nakamura, Takeshi
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093328/
https://www.ncbi.nlm.nih.gov/pubmed/21460187
http://dx.doi.org/10.1091/mbc.E10-09-0783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093328/
https://www.ncbi.nlm.nih.gov/pubmed/21460187
http://dx.doi.org/10.1091/mbc.E10-09-0783

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