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Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain
Forkhead transcription factors (FOXOs) alter a diverse array of cellular processes including the cell cycle, oxidative stress resistance, and aging. Insulin/Akt activation directs phosphorylation and cytoplasmic sequestration of FOXO away from its target genes and serves as an endpoint of a complex...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093329/ https://www.ncbi.nlm.nih.gov/pubmed/21460183 http://dx.doi.org/10.1091/mbc.E10-10-0854 |