Exhaustive Sampling of Docking Poses Reveals Binding Hypotheses for Propafenone Type Inhibitors of P-Glycoprotein

Overexpression of the xenotoxin transporter P-glycoprotein (P-gp) represents one major reason for the development of multidrug resistance (MDR), leading to the failure of antibiotic and cancer therapies. Inhibitors of P-gp have thus been advocated as promising candidates for overcoming the problem o...

Descripción completa

Detalles Bibliográficos
Autores principales: Klepsch, Freya, Chiba, Peter, Ecker, Gerhard F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093348/
https://www.ncbi.nlm.nih.gov/pubmed/21589945
http://dx.doi.org/10.1371/journal.pcbi.1002036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093348/
https://www.ncbi.nlm.nih.gov/pubmed/21589945
http://dx.doi.org/10.1371/journal.pcbi.1002036

Ejemplares similares