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Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response
Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial. The aim of this study is to analyze methadone dosage in responder and no...
Autores principales: | Fonseca, Francina, de la Torre, Rafael, Díaz, Laura, Pastor, Antonio, Cuyàs, Elisabet, Pizarro, Nieves, Khymenets, Olha, Farré, Magí, Torrens, Marta |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093392/ https://www.ncbi.nlm.nih.gov/pubmed/21589866 http://dx.doi.org/10.1371/journal.pone.0019527 |
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