Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors

[Image: see text] A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC(50) values of 70, 40, and 20 nM in Tel-ALK transformed Ba/F3 cells, respectiv...

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Detalles Bibliográficos
Autores principales: Deng, Xianming, Wang, Jinhua, Zhang, Jianming, Sim, Taebo, Kim, Nam Doo, Sasaki, Takaaki, Luther, William, George, Rani E., Jänne, Pasi A., Gray, Nathanael S.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093683/
https://www.ncbi.nlm.nih.gov/pubmed/21572589
http://dx.doi.org/10.1021/ml200002a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093683/
https://www.ncbi.nlm.nih.gov/pubmed/21572589
http://dx.doi.org/10.1021/ml200002a

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