Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences

BACKGROUND: Replication of mammalian genomes requires the activation of thousands of origins which are both spatially and temporally regulated by as yet unknown mechanisms. At the most fundamental level, our knowledge about the distribution pattern of origins in each of the chromosomes, among differ...

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Detalles Bibliográficos
Autores principales: Valenzuela, Manuel S., Chen, Yidong, Davis, Sean, Yang, Fan, Walker, Robert L., Bilke, Sven, Lueders, John, Martin, Melvenia M., Aladjem, Mirit I., Massion, Pierre P., Meltzer, Paul S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094316/
https://www.ncbi.nlm.nih.gov/pubmed/21602917
http://dx.doi.org/10.1371/journal.pone.0017308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094316/
https://www.ncbi.nlm.nih.gov/pubmed/21602917
http://dx.doi.org/10.1371/journal.pone.0017308

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