Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target

Undecaprenyl pyrophosphate synthase is a cis-prenyltransferase enzyme, which is required for cell wall biosynthesis in bacteria. Undecaprenyl pyrophosphate synthase is an attractive target for antimicrobial therapy. We performed long molecular dynamics simulations and docking studies on undecaprenyl...

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Detalles Bibliográficos
Autores principales: Sinko, William, de Oliveira, César, Williams, Sarah, Van Wynsberghe, Adam, Durrant, Jacob D, Cao, Rong, Oldfield, Eric, McCammon, J Andrew
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095679/
https://www.ncbi.nlm.nih.gov/pubmed/21294851
http://dx.doi.org/10.1111/j.1747-0285.2011.01101.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095679/
https://www.ncbi.nlm.nih.gov/pubmed/21294851
http://dx.doi.org/10.1111/j.1747-0285.2011.01101.x

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