Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase

The use of E. coli purine nucleoside phosphorylase (PNP) to activate prodrugs has demonstrated excellent activity in the treatment of various human tumor xenografts in mice. E. coli PNP cleaves purine nucleoside analogs to generate toxic adenine analogs, which are activated by adenine phosphoribosyl...

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Detalles Bibliográficos
Autores principales: Parker, W B, Allan, P W, Waud, W R, Hong, J S, Sorscher, E J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096718/
https://www.ncbi.nlm.nih.gov/pubmed/21394111
http://dx.doi.org/10.1038/cgt.2011.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096718/
https://www.ncbi.nlm.nih.gov/pubmed/21394111
http://dx.doi.org/10.1038/cgt.2011.4

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