Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

BACKGROUND: The C-terminal domain (CTD) of HIV-1 capsid (CA), like full-length CA, forms dimers in solution and CTD dimerization is a major driving force in Gag assembly and maturation. Mutations of the residues at the CTD dimer interface impair virus assembly and render the virus non-infectious. Th...

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Detalles Bibliográficos
Autores principales: Zhang, Hongtao, Curreli, Francesca, Zhang, Xihui, Bhattacharya, Shibani, Waheed, Abdul A, Cooper, Alan, Cowburn, David, Freed, Eric O, Debnath, Asim K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097154/
https://www.ncbi.nlm.nih.gov/pubmed/21539734
http://dx.doi.org/10.1186/1742-4690-8-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097154/
https://www.ncbi.nlm.nih.gov/pubmed/21539734
http://dx.doi.org/10.1186/1742-4690-8-28

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