Sphingosine Kinase 1 Regulates the Akt/FOXO3a/Bim Pathway and Contributes to Apoptosis Resistance in Glioma Cells

The aim of this study was to investigate the mechanism through which Sphingosine kinase-1 (SPHK1) exerts its anti-apoptosis activity in glioma cancer cells. We here report that dysregulation of SPHK1 alters the sensitivity of glioma to apoptosis both in vitro and in vivo. Further mechanistic study e...

Descripción completa

Detalles Bibliográficos
Autores principales: Guan, Hongyu, Song, Libing, Cai, Junchao, Huang, Yongbo, Wu, Jueheng, Yuan, Jie, Li, Jun, Li, Mengfeng
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097221/
https://www.ncbi.nlm.nih.gov/pubmed/21625639
http://dx.doi.org/10.1371/journal.pone.0019946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097221/
https://www.ncbi.nlm.nih.gov/pubmed/21625639
http://dx.doi.org/10.1371/journal.pone.0019946

Ejemplares similares