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Sphingosine Kinase 1 Regulates the Akt/FOXO3a/Bim Pathway and Contributes to Apoptosis Resistance in Glioma Cells

The aim of this study was to investigate the mechanism through which Sphingosine kinase-1 (SPHK1) exerts its anti-apoptosis activity in glioma cancer cells. We here report that dysregulation of SPHK1 alters the sensitivity of glioma to apoptosis both in vitro and in vivo. Further mechanistic study e...

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Detalles Bibliográficos
Autores principales:	Guan, Hongyu, Song, Libing, Cai, Junchao, Huang, Yongbo, Wu, Jueheng, Yuan, Jie, Li, Jun, Li, Mengfeng
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097221/ https://www.ncbi.nlm.nih.gov/pubmed/21625639 http://dx.doi.org/10.1371/journal.pone.0019946

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