Cell-Intrinsic NF-κB Activation Is Critical for the Development of Natural Regulatory T Cells in Mice

BACKGROUND: Naturally occurring CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells develop in the thymus and represent a mature T cell subpopulation critically involved in maintaining peripheral tolerance. The differentiation of Treg cells in the thymus requires T cell receptor (TCR)/CD28 stimulation a...

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Detalles Bibliográficos
Autores principales: Gückel, Eva, Frey, Silke, Zaiss, Mario M., Schett, Georg, Ghosh, Sankar, Voll, Reinhard E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097234/
https://www.ncbi.nlm.nih.gov/pubmed/21625598
http://dx.doi.org/10.1371/journal.pone.0020003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097234/
https://www.ncbi.nlm.nih.gov/pubmed/21625598
http://dx.doi.org/10.1371/journal.pone.0020003

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