Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice

Abnormal Notch signaling in humans results in Alagille syndrome, a pleiotropic disease characterized by a paucity of intrahepatic bile ducts (IHBDs). It is not clear how IHBD paucity develops as a consequence of atypical Notch signaling, whether by a developmental lack of bile duct formation, a post...

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Detalles Bibliográficos
Autores principales: Sparks, Erin E., Perrien, Daniel S., Huppert, Kari A., Peterson, Todd E., Huppert, Stacey S.
Formato: Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097457/
https://www.ncbi.nlm.nih.gov/pubmed/21282722
http://dx.doi.org/10.1242/dmm.005793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097457/
https://www.ncbi.nlm.nih.gov/pubmed/21282722
http://dx.doi.org/10.1242/dmm.005793

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