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Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice
Abnormal Notch signaling in humans results in Alagille syndrome, a pleiotropic disease characterized by a paucity of intrahepatic bile ducts (IHBDs). It is not clear how IHBD paucity develops as a consequence of atypical Notch signaling, whether by a developmental lack of bile duct formation, a post...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097457/ https://www.ncbi.nlm.nih.gov/pubmed/21282722 http://dx.doi.org/10.1242/dmm.005793 |