Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan syndrome is associated with dysregulation of the Ras–mitogen-activated-protein-kinase (MAPK) signaling pathway. Recently, two mutations in NRAS we...

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Detalles Bibliográficos
Autores principales: Runtuwene, Vincent, van Eekelen, Mark, Overvoorde, John, Rehmann, Holger, Yntema, Helger G., Nillesen, Willy M., van Haeringen, Arie, van der Burgt, Ineke, Burgering, Boudewijn, den Hertog, Jeroen
Formato: Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097460/
https://www.ncbi.nlm.nih.gov/pubmed/21263000
http://dx.doi.org/10.1242/dmm.007112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097460/
https://www.ncbi.nlm.nih.gov/pubmed/21263000
http://dx.doi.org/10.1242/dmm.007112

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