New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some...

Descripción completa

Detalles Bibliográficos
Autores principales: Hampl, Veronika, Wetzel, Isolde, Bracher, Franz, Krauss, Jürgen
Formato: Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097510/
https://www.ncbi.nlm.nih.gov/pubmed/21617770
http://dx.doi.org/10.3797/scipharm.1011-10
_version_ 1782203831160930304
author Hampl, Veronika
Wetzel, Isolde
Bracher, Franz
Krauss, Jürgen
author_facet Hampl, Veronika
Wetzel, Isolde
Bracher, Franz
Krauss, Jürgen
author_sort Hampl, Veronika
collection PubMed
description New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).
format Text
id pubmed-3097510
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Österreichische Apotheker-Verlagsgesellschaft
record_format MEDLINE/PubMed
spelling pubmed-30975102011-05-26 New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities Hampl, Veronika Wetzel, Isolde Bracher, Franz Krauss, Jürgen Sci Pharm Research Article New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60). Österreichische Apotheker-Verlagsgesellschaft 2011 2010-12-18 /pmc/articles/PMC3097510/ /pubmed/21617770 http://dx.doi.org/10.3797/scipharm.1011-10 Text en © Hampl et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hampl, Veronika
Wetzel, Isolde
Bracher, Franz
Krauss, Jürgen
New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
title New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
title_full New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
title_fullStr New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
title_full_unstemmed New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
title_short New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities
title_sort new substituted isocoumarins and dihydroisocoumarins and their cytotoxic activities
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097510/
https://www.ncbi.nlm.nih.gov/pubmed/21617770
http://dx.doi.org/10.3797/scipharm.1011-10
work_keys_str_mv AT hamplveronika newsubstitutedisocoumarinsanddihydroisocoumarinsandtheircytotoxicactivities
AT wetzelisolde newsubstitutedisocoumarinsanddihydroisocoumarinsandtheircytotoxicactivities
AT bracherfranz newsubstitutedisocoumarinsanddihydroisocoumarinsandtheircytotoxicactivities
AT kraussjurgen newsubstitutedisocoumarinsanddihydroisocoumarinsandtheircytotoxicactivities

Ejemplares similares