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Free Energy Simulations of a GTPase: GTP and GDP Binding to Archaeal Initiation Factor 2
[Image: see text] Archaeal initiation factor 2 (aIF2) is a protein involved in the initiation of protein biosynthesis. In its GTP-bound, “ON” conformation, aIF2 binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, “OFF” conformation, it dissociates from tRNA. To understand the s...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097523/ https://www.ncbi.nlm.nih.gov/pubmed/21534562 http://dx.doi.org/10.1021/jp201934p |