Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology

BACKGROUND: In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centrality-lethality rule", which indicates that the topological placement of a protein in PPI network is connected with its...

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Detalles Bibliográficos
Autores principales: Ning, Kang, Ng, Hoong Kee, Srihari, Sriganesh, Leong, Hon Wai, Nesvizhskii, Alexey I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098085/
https://www.ncbi.nlm.nih.gov/pubmed/20939873
http://dx.doi.org/10.1186/1471-2105-11-505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098085/
https://www.ncbi.nlm.nih.gov/pubmed/20939873
http://dx.doi.org/10.1186/1471-2105-11-505

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