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Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology
BACKGROUND: In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centrality-lethality rule", which indicates that the topological placement of a protein in PPI network is connected with its...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098085/ https://www.ncbi.nlm.nih.gov/pubmed/20939873 http://dx.doi.org/10.1186/1471-2105-11-505 |