A General Model for Binary Cell Fate Decision Gene Circuits with Degeneracy: Indeterminacy and Switch Behavior in the Absence of Cooperativity

BACKGROUND: The gene regulatory circuit motif in which two opposing fate-determining transcription factors inhibit each other but activate themselves has been used in mathematical models of binary cell fate decisions in multipotent stem or progenitor cells. This simple circuit can generate multistab...

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Detalles Bibliográficos
Autores principales: Andrecut, Mircea, Halley, Julianne D., Winkler, David A., Huang, Sui
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098230/
https://www.ncbi.nlm.nih.gov/pubmed/21625586
http://dx.doi.org/10.1371/journal.pone.0019358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098230/
https://www.ncbi.nlm.nih.gov/pubmed/21625586
http://dx.doi.org/10.1371/journal.pone.0019358

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