Acyclic Identification of Aptamers for Human alpha-Thrombin Using Over-Represented Libraries and Deep Sequencing

BACKGROUND: Aptamers are oligonucleotides that bind proteins and other targets with high affinity and selectivity. Twenty years ago elements of natural selection were adapted to in vitro selection in order to distinguish aptamers among randomized sequence libraries. The primary bottleneck in traditi...

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Detalles Bibliográficos
Autores principales: Kupakuwana, Gillian V., Crill, James E., McPike, Mark P., Borer, Philip N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098231/
https://www.ncbi.nlm.nih.gov/pubmed/21625587
http://dx.doi.org/10.1371/journal.pone.0019395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098231/
https://www.ncbi.nlm.nih.gov/pubmed/21625587
http://dx.doi.org/10.1371/journal.pone.0019395

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