Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

Huntington's disease (HD) is a neurodegenerative disorder due to abnormal polyglutamine expansion in huntingtin protein (Exp-Htt). This expansion causes protein aggregation, leading to neuronal dysfunction and death. We have previously shown that mitogen- and stress-activated kinase (MSK-1), a...

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Detalles Bibliográficos
Autores principales: Martin, Elodie, Betuing, Sandrine, Pagès, Christiane, Cambon, Karine, Auregan, Gwenaelle, Deglon, Nicole, Roze, Emmanuel, Caboche, Jocelyne
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098728/
https://www.ncbi.nlm.nih.gov/pubmed/21493629
http://dx.doi.org/10.1093/hmg/ddr148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098728/
https://www.ncbi.nlm.nih.gov/pubmed/21493629
http://dx.doi.org/10.1093/hmg/ddr148

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