Engineering of Insulin Receptor Isoform-Selective Insulin Analogues

BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to the region where the A and B isoforms differ. Th...

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Detalles Bibliográficos
Autores principales: Glendorf, Tine, Stidsen, Carsten E., Norrman, Mathias, Nishimura, Erica, Sørensen, Anders R., Kjeldsen, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098868/
https://www.ncbi.nlm.nih.gov/pubmed/21625452
http://dx.doi.org/10.1371/journal.pone.0020288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098868/
https://www.ncbi.nlm.nih.gov/pubmed/21625452
http://dx.doi.org/10.1371/journal.pone.0020288

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