Cargando…

Engineering of Insulin Receptor Isoform-Selective Insulin Analogues

BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to the region where the A and B isoforms differ. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glendorf, Tine, Stidsen, Carsten E., Norrman, Mathias, Nishimura, Erica, Sørensen, Anders R., Kjeldsen, Thomas
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098868/ https://www.ncbi.nlm.nih.gov/pubmed/21625452 http://dx.doi.org/10.1371/journal.pone.0020288

Ejemplares similares

Systematic Evaluation of the Metabolic to Mitogenic Potency Ratio for B10-Substituted Insulin Analogues
por: Glendorf, Tine, et al.
Publicado: (2012)

Molecular Characterisation of Long-Acting Insulin Analogues in Comparison with Human Insulin, IGF-1 and Insulin X10
por: Hansen, Bo F., et al.
Publicado: (2012)

Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing
por: Nishimura, Erica, et al.
Publicado: (2021)

Novel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin Dimerization
por: Vinther, Tine N., et al.
Publicado: (2012)

Molecular engineering of safe and efficacious oral basal insulin
por: Hubálek, Frantisek, et al.
Publicado: (2020)

Author Correction: Molecular engineering of safe and efficacious oral basal insulin
por: Hubálek, Frantisek, et al.
Publicado: (2020)

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
por: Jiráček, Jiří, et al.
Publicado: (2017)

Insulin Receptor Isoforms in Cancer
por: Vella, Veronica, et al.
Publicado: (2018)

Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo
por: Hvid, Henning, et al.
Publicado: (2020)

Chymotrypsin substrate analogues inhibit endocytosis of insulin and insulin receptors in adipocytes
Publicado: (1986)

Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH
por: Norrman, Mathias, et al.
Publicado: (2007)

Altered Expression of Insulin Receptor Isoforms in Breast Cancer
por: Huang, Jiaqi, et al.
Publicado: (2011)

Insulin Receptor Isoform Variations in Prostate Cancer Cells
por: Perks, Claire M., et al.
Publicado: (2016)

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance
por: Galal, Mariam Ahmed, et al.
Publicado: (2023)

Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps
por: Valla, Vasiliki
Publicado: (2010)

Insulin Degludec Aspart: The First Co-formulation of Insulin Analogues
por: Kalra, Sanjay
Publicado: (2014)

Insulin Receptor Isoforms A and B as well as Insulin Receptor Substrates-1 and -2 Are Differentially Expressed in Prostate Cancer
por: Heni, Martin, et al.
Publicado: (2012)

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718
por: Andersen, Mie, et al.
Publicado: (2017)

Production costs and potential prices for biosimilars of human insulin and insulin analogues
por: Gotham, Dzintars, et al.
Publicado: (2018)

Human Insulin Versus Insulin Analogues: A True Companion Forgotten
por: Abdi, Hengameh
Publicado: (2019)

Cardioprotective role of insulin: Advantage analogues
por: Maiti, Rituparna, et al.
Publicado: (2012)

Safety and Efficacy of Modern Insulin Analogues
por: Yoo, Hye Jin, et al.
Publicado: (2013)

Immunologic Tolerance to the Insulin Analogue Glulisine
por: Ozaki, Nobuaki, et al.
Publicado: (2010)

The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications
por: Escribano, O., et al.
Publicado: (2017)

Insulin Icodec Weekly: A Basal Insulin Analogue for Type 2 Diabetes
por: Bajaj, Harpreet S, et al.
Publicado: (2023)

PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble
por: Sharma, Medha, et al.
Publicado: (2022)

Metabolic effect and receptor signalling profile of a non-metabolisable insulin glargine analogue
por: Werner, Ulrich, et al.
Publicado: (2014)

Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation
por: Vella, Veronica, et al.
Publicado: (2019)

Current european regulatory perspectives on insulin analogues
por: Enzmann, Harald G, et al.
Publicado: (2011)

The metabolic and mitogenic properties of basal insulin analogues
por: Tennagels, Norbert, et al.
Publicado: (2013)

Review of Insulin and its Analogues in Diabetes Mellitus
por: Mane, Krishnappa, et al.
Publicado: (2012)

Degludec: the new ultra-long insulin analogue
por: Tambascia, Marcos Antonio, et al.
Publicado: (2015)

Characterisation of insulin analogues therapeutically available to patients
por: Adams, Gary G., et al.
Publicado: (2018)

Isoform-specific insulin receptor signaling involves different plasma membrane domains
por: Uhles, Sabine, et al.
Publicado: (2003)

Overexpression of the Insulin Receptor Isoform A Promotes Endometrial Carcinoma Cell Growth
por: Wang, Chun-Fang, et al.
Publicado: (2013)

Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure–Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities
por: Haider, Saqlain, et al.
Publicado: (2021)

Synchronization in G(0)/G(1) enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin
por: Bonnesen, Christine, et al.
Publicado: (2009)

The Effects of Anti-insulin Antibodies and Cross-reactivity with Human Recombinant Insulin Analogues in the E170 Insulin Immunometric Assay
por: Kim, Serim, et al.
Publicado: (2011)

Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis
por: Beneit, Nuria, et al.
Publicado: (2018)

Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
por: Hemkens, L. G., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_hhss1b85o94ibksc3a4vh5qm5g