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Molecular Structure of Amyloid Fibrils Controls the Relationship between Fibrillar Size and Toxicity

BACKGROUND: According to the prevailing view, soluble oligomers or small fibrillar fragments are considered to be the most toxic species in prion diseases. To test this hypothesis, two conformationally different amyloid states were produced from the same highly pure recombinant full-length prion pro...

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Detalles Bibliográficos
Autores principales: Lee, Young Jin, Savtchenko, Regina, Ostapchenko, Valeriy G., Makarava, Natallia, Baskakov, Ilia V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098877/
https://www.ncbi.nlm.nih.gov/pubmed/21625461
http://dx.doi.org/10.1371/journal.pone.0020244