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Molecular Structure of Amyloid Fibrils Controls the Relationship between Fibrillar Size and Toxicity
BACKGROUND: According to the prevailing view, soluble oligomers or small fibrillar fragments are considered to be the most toxic species in prion diseases. To test this hypothesis, two conformationally different amyloid states were produced from the same highly pure recombinant full-length prion pro...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098877/ https://www.ncbi.nlm.nih.gov/pubmed/21625461 http://dx.doi.org/10.1371/journal.pone.0020244 |