Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

In the hippocampal formation of Alzheimer’s disease (AD) patients, both focal and diffuse deposits of Aβ peptides appear in a subregion- and layer-specific manner. Recently, pyroglutamate (pGlu or pE)-modified Aβ peptides were identified as a highly pathogenic and seeding Aβ peptide species. Since t...

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Detalles Bibliográficos
Autores principales: Hartlage-Rübsamen, Maike, Morawski, Markus, Waniek, Alexander, Jäger, Carsten, Zeitschel, Ulrike, Koch, Birgit, Cynis, Holger, Schilling, Stephan, Schliebs, Reinhard, Demuth, Hans-Ulrich, Roßner, Steffen
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098988/
https://www.ncbi.nlm.nih.gov/pubmed/21301857
http://dx.doi.org/10.1007/s00401-011-0806-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098988/
https://www.ncbi.nlm.nih.gov/pubmed/21301857
http://dx.doi.org/10.1007/s00401-011-0806-2

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