Genomic DNA Pooling Strategy for Next-Generation Sequencing-Based Rare Variant Discovery in Abdominal Aortic Aneurysm Regions of Interest—Challenges and Limitations

The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA...

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Detalles Bibliográficos
Autores principales: Harakalova, Magdalena, Nijman, Isaäc J., Medic, Jelena, Mokry, Michal, Renkens, Ivo, Blankensteijn, Jan D., Kloosterman, Wigard, Baas, Annette F., Cuppen, Edwin
Formato: Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099005/
https://www.ncbi.nlm.nih.gov/pubmed/21360310
http://dx.doi.org/10.1007/s12265-011-9263-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099005/
https://www.ncbi.nlm.nih.gov/pubmed/21360310
http://dx.doi.org/10.1007/s12265-011-9263-5

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