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A Single Amino Acid Residue Constitutes the Third Dimerization Domain Essential for the Assembly and Function of the Tetrameric Polycystin-2 (TRPP2) Channel

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited cause of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2 (15%). The PKD2 protein, polycystin-2 (PC2 or TRPP2), is a member of the transient receptor potential (TRP) superfamily and functions as a nons...

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Detalles Bibliográficos
Autores principales: Feng, Shuang, Rodat-Despoix, Lise, Delmas, Patrick, Ong, Albert C. M.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099714/
https://www.ncbi.nlm.nih.gov/pubmed/21474446
http://dx.doi.org/10.1074/jbc.M110.192286