The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease

Accumulating evidence indicates that oxidative stress plays a critical role in Parkinson's disease (PD). Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phe...

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Autores principales: Wang, Haomin, Pan, Yanli, Xue, Bing, Wang, Xinhong, Zhao, Feng, Jia, Jun, Liang, Xibin, Wang, Xiaomin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100295/
https://www.ncbi.nlm.nih.gov/pubmed/21625423
http://dx.doi.org/10.1371/journal.pone.0019790
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author Wang, Haomin
Pan, Yanli
Xue, Bing
Wang, Xinhong
Zhao, Feng
Jia, Jun
Liang, Xibin
Wang, Xiaomin
author_facet Wang, Haomin
Pan, Yanli
Xue, Bing
Wang, Xinhong
Zhao, Feng
Jia, Jun
Liang, Xibin
Wang, Xiaomin
author_sort Wang, Haomin
collection PubMed
description Accumulating evidence indicates that oxidative stress plays a critical role in Parkinson's disease (PD). Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in male C57BL/6 mice, a model of PD. In the present study we administered 100 Hz EA stimulation at the two acupoints to MPTP-lesioned mice for 12 sessions starting from the day prior to the first MPTP injection. We found that in the striatum of MPTP treated mice 100 Hz EA stimulation effectively inhibited the production of hydrogen peroxide and malonaldehyde, and increased glutathione concentration and total superoxide dismutase activity through biochemical methods. However, it decreased glutathione peroxidase activity via biochemical analysis and did not affect the level of 1-methyl-4-phenylpyridinium in the striatum revealed by high performance liquid chromatography with ultraviolet detection. These data suggest that 100 Hz EA stimulation at ST36 and SP6 has antioxidative effects in the MPTP model of PD. This data, along with our previous work, indicates that 100 Hz EA stimulation at ST36 and SP6 protects the nigrostriatal system by multiple mechanisms including antioxidation and antiapoptosis, and suggests that EA stimulation is a promising therapy for treating PD.
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spelling pubmed-31002952011-05-27 The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease Wang, Haomin Pan, Yanli Xue, Bing Wang, Xinhong Zhao, Feng Jia, Jun Liang, Xibin Wang, Xiaomin PLoS One Research Article Accumulating evidence indicates that oxidative stress plays a critical role in Parkinson's disease (PD). Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in male C57BL/6 mice, a model of PD. In the present study we administered 100 Hz EA stimulation at the two acupoints to MPTP-lesioned mice for 12 sessions starting from the day prior to the first MPTP injection. We found that in the striatum of MPTP treated mice 100 Hz EA stimulation effectively inhibited the production of hydrogen peroxide and malonaldehyde, and increased glutathione concentration and total superoxide dismutase activity through biochemical methods. However, it decreased glutathione peroxidase activity via biochemical analysis and did not affect the level of 1-methyl-4-phenylpyridinium in the striatum revealed by high performance liquid chromatography with ultraviolet detection. These data suggest that 100 Hz EA stimulation at ST36 and SP6 has antioxidative effects in the MPTP model of PD. This data, along with our previous work, indicates that 100 Hz EA stimulation at ST36 and SP6 protects the nigrostriatal system by multiple mechanisms including antioxidation and antiapoptosis, and suggests that EA stimulation is a promising therapy for treating PD. Public Library of Science 2011-05-23 /pmc/articles/PMC3100295/ /pubmed/21625423 http://dx.doi.org/10.1371/journal.pone.0019790 Text en Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Haomin
Pan, Yanli
Xue, Bing
Wang, Xinhong
Zhao, Feng
Jia, Jun
Liang, Xibin
Wang, Xiaomin
The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease
title The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease
title_full The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease
title_fullStr The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease
title_full_unstemmed The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease
title_short The Antioxidative Effect of Electro-Acupuncture in a Mouse Model of Parkinson's Disease
title_sort antioxidative effect of electro-acupuncture in a mouse model of parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100295/
https://www.ncbi.nlm.nih.gov/pubmed/21625423
http://dx.doi.org/10.1371/journal.pone.0019790
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