Polyene Macrolide Antifungal Drugs Trigger Interleukin-1β Secretion by Activating the NLRP3 Inflammasome

The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but the molecular mechanism is unknown. Here we r...

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Detalles Bibliográficos
Autores principales: Darisipudi, Murthy Narayana, Allam, Ramanjaneyulu, Rupanagudi, Khader Valli, Anders, Hans-Joachim
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100296/
https://www.ncbi.nlm.nih.gov/pubmed/21625424
http://dx.doi.org/10.1371/journal.pone.0019588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100296/
https://www.ncbi.nlm.nih.gov/pubmed/21625424
http://dx.doi.org/10.1371/journal.pone.0019588

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