Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

BACKGROUND: Patterns of emerging drug resistance reflect the underlying adaptive landscapes for specific drugs. In Plasmodium falciparum, the parasite that causes the most serious form of malaria, antifolate drugs inhibit the function of essential enzymes in the folate pathway. However, a handful of...

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Detalles Bibliográficos
Autores principales: Costanzo, Marna S., Brown, Kyle M., Hartl, Daniel L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100297/
https://www.ncbi.nlm.nih.gov/pubmed/21625425
http://dx.doi.org/10.1371/journal.pone.0019636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100297/
https://www.ncbi.nlm.nih.gov/pubmed/21625425
http://dx.doi.org/10.1371/journal.pone.0019636

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