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PTHrP Induces Autocrine/Paracrine Proliferation of Bone Tumor Cells through Inhibition of Apoptosis

Giant Cell Tumor of Bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates and metastatic potential. Previous work in our lab has shown that the neoplastic cell of GCT is a proliferating pre-osteoblastic stromal cell in which the transcription facto...

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Detalles Bibliográficos
Autores principales: Mak, Isabella W. Y., Cowan, Robert W., Turcotte, Robert E., Singh, Gurmit, Ghert, Michelle
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100318/
https://www.ncbi.nlm.nih.gov/pubmed/21625386
http://dx.doi.org/10.1371/journal.pone.0019975