Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse

BACKGROUND: Clinical use of selective inhibitors of cyclooxygenase (COX)-2 appears associated with increased risk of thrombotic events. This is often hypothesised to reflect reduction in anti-thrombotic prostanoids, notably PGI(2), formed by COX-2 present within endothelial cells. However, whether C...

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Detalles Bibliográficos
Autores principales: Armstrong, Paul C., Kirkby, Nicholas S., Zain, Zetty N., Emerson, Michael, Mitchell, Jane A., Warner, Timothy D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100333/
https://www.ncbi.nlm.nih.gov/pubmed/21629780
http://dx.doi.org/10.1371/journal.pone.0020062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100333/
https://www.ncbi.nlm.nih.gov/pubmed/21629780
http://dx.doi.org/10.1371/journal.pone.0020062

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