Genetic Variation in CYP3A43 Explains Racial Difference in Olanzapine Clearance

The antipsychotic drug, olanzapine, one of the most widely used drugs in clinical medicine, has a high rate of discontinuation due to inefficacy and/or adverse effects. We identified a SNP in the drug metabolizing enzyme cytochrome, P450 3A43 (CYP3A43; rs472660) that highly significantly predicted o...

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Detalles Bibliográficos
Autores principales: Bigos, Kristin L., Bies, Robert R., Pollock, Bruce G., Lowy, Joshua J., Zhang, Fengyu, Weinberger, Daniel R.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100476/
https://www.ncbi.nlm.nih.gov/pubmed/21519338
http://dx.doi.org/10.1038/mp.2011.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100476/
https://www.ncbi.nlm.nih.gov/pubmed/21519338
http://dx.doi.org/10.1038/mp.2011.38

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