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Genetic Variation in CYP3A43 Explains Racial Difference in Olanzapine Clearance
The antipsychotic drug, olanzapine, one of the most widely used drugs in clinical medicine, has a high rate of discontinuation due to inefficacy and/or adverse effects. We identified a SNP in the drug metabolizing enzyme cytochrome, P450 3A43 (CYP3A43; rs472660) that highly significantly predicted o...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100476/ https://www.ncbi.nlm.nih.gov/pubmed/21519338 http://dx.doi.org/10.1038/mp.2011.38 |