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Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition
[Image: see text] The BRCA1 BRCT domain binds pSer-x-x-Phe motifs in partner proteins to regulate the cellular response to DNA damage. Approximately 120 distinct missense variants have been identified in the BRCA1 BRCT through breast cancer screening, and several of these have been linked to an incr...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100782/ https://www.ncbi.nlm.nih.gov/pubmed/21473589 http://dx.doi.org/10.1021/bi2003795 |