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Benzbromarone Stabilizes ΔF508 CFTR at the Cell Surface
[Image: see text] Deletion of Phe508 from the first nucleotide-binding domain of the CFTR chloride channel causes cystic fibrosis because it inhibits protein folding. Indirect approaches such as incubation at low temperatures can partially rescue ΔF508 CFTR, but the protein is unstable at the cell s...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100783/ https://www.ncbi.nlm.nih.gov/pubmed/21520952 http://dx.doi.org/10.1021/bi2004813 |