A novel role for BRCA1 in regulating breast cancer cell spreading and motility

BRCA1 C-terminal (BRCT) domains in BRCA1 are essential for tumor suppressor function, though the underlying mechanisms remain unclear. We identified ezrin, radixin, and moesin as BRCA1 BRCT domain–interacting proteins. Ezrin–radixin–moesin (ERM) and F-actin colocalized with BRCA1 at the plasma membr...

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Detalles Bibliográficos
Autores principales: Coene, Elisabeth D., Gadelha, Catarina, White, Nicholas, Malhas, Ashraf, Thomas, Benjamin, Shaw, Michael, Vaux, David J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101087/
https://www.ncbi.nlm.nih.gov/pubmed/21282464
http://dx.doi.org/10.1083/jcb.201004136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101087/
https://www.ncbi.nlm.nih.gov/pubmed/21282464
http://dx.doi.org/10.1083/jcb.201004136

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