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Replication protein A safeguards genome integrity by controlling NER incision events
Single-stranded DNA gaps that might arise by futile repair processes can lead to mutagenic events and challenge genome integrity. Nucleotide excision repair (NER) is an evolutionarily conserved repair mechanism, essential for removal of helix-distorting DNA lesions. In the currently prevailing model...
Autores principales: | Overmeer, René M., Moser, Jill, Volker, Marcel, Kool, Hanneke, Tomkinson, Alan E., van Zeeland, Albert A., Mullenders, Leon H.F., Fousteri, Maria |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101093/ https://www.ncbi.nlm.nih.gov/pubmed/21282463 http://dx.doi.org/10.1083/jcb.201006011 |
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