Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

Aminoglycoside antibiotics target the ribosomal decoding A-site and are active against a broad spectrum of bacteria. These compounds bind to a highly conserved stem-loop-stem structure in helix 44 of bacterial 16S rRNA. One particular aminoglycoside, paromomycin, also shows potent antiprotozoal acti...

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Detalles Bibliográficos
Autores principales: Hobbie, Sven N., Kaiser, Marcel, Schmidt, Sebastian, Shcherbakov, Dmitri, Janusic, Tanja, Brun, Reto, Böttger, Erik C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101183/
https://www.ncbi.nlm.nih.gov/pubmed/21629725
http://dx.doi.org/10.1371/journal.pntd.0001161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101183/
https://www.ncbi.nlm.nih.gov/pubmed/21629725
http://dx.doi.org/10.1371/journal.pntd.0001161

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