A Synthetic HIV-1 Subtype C Backbone Generates Comparable PR and RT Resistance Profiles to a Subtype B Backbone in a Recombinant Virus Assay

In order to determine phenotypic protease and reverse transcriptase inhibitor-associated resistance in HIV subtype C virus, we have synthetically constructed an HIV-1 subtype C (HIV-1-C) viral backbone for use in a recombinant virus assay. The in silico designed viral genome was divided into 4 fragm...

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Detalles Bibliográficos
Autores principales: Nauwelaers, David, Van Houtte, Margriet, Winters, Bart, Steegen, Kim, Van Baelen, Kurt, Chi, Ellen, Zhou, Mimi, Steiner, Derek, Bonesteel, Rachelle, Aston, Colin, Stuyver, Lieven J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101197/
https://www.ncbi.nlm.nih.gov/pubmed/21629677
http://dx.doi.org/10.1371/journal.pone.0019643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101197/
https://www.ncbi.nlm.nih.gov/pubmed/21629677
http://dx.doi.org/10.1371/journal.pone.0019643

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