Cargando…

Frataxin participates to the hypoxia-induced response in tumors

Defective expression of frataxin is responsible for the degenerative disease Friedreich's ataxia. Frataxin is a protein required for cell survival since complete knockout is lethal. Frataxin protects tumor cells against oxidative stress and apoptosis but also acts as a tumor suppressor. The mol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guccini, I, Serio, D, Condò, I, Rufini, A, Tomassini, B, Mangiola, A, Maira, G, Anile, C, Fina, D, Pallone, F, Mongiardi, M P, Levi, A, Ventura, N, Testi, R, Malisan, F
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101705/ https://www.ncbi.nlm.nih.gov/pubmed/21368894 http://dx.doi.org/10.1038/cddis.2011.5

Ejemplares similares

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia
por: Benini, Monica, et al.
Publicado: (2017)

Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model
por: Tomassini, Barbara, et al.
Publicado: (2012)

Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells
por: Rufini, Alessandra, et al.
Publicado: (2015)

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans
por: Schiavi, Alfonso, et al.
Publicado: (2013)

Drug Repositioning in Friedreich Ataxia
por: Rufini, Alessandra, et al.
Publicado: (2022)

Corrigendum to “Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans” [Exp. Gerontol. 48 (2013) 191–201]
por: Schiavi, Alfonso, et al.
Publicado: (2013)

Acetylation Suppresses the Proapoptotic Activity of GD3 Ganglioside
por: Malisan, Florence, et al.
Publicado: (2002)

Biophysical characterisation of the recombinant human frataxin precursor
por: Castro, Ignacio Hugo, et al.
Publicado: (2018)

Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich’s Ataxia Cells
por: Luffarelli, Riccardo, et al.
Publicado: (2023)

SINEUP non-coding RNAs rescue defective frataxin expression and activity in a cellular model of Friedreich's Ataxia
por: Bon, Carlotta, et al.
Publicado: (2019)

Plant Frataxin in Metal Metabolism
por: Gomez-Casati, Diego F., et al.
Publicado: (2018)

Simultaneous Quantification of Mitochondrial Mature Frataxin and Extra-Mitochondrial Frataxin Isoform E in Friedreich’s Ataxia Blood
por: Wang, Qingqing, et al.
Publicado: (2022)

Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich’s ataxia
por: Hackett, Peter T., et al.
Publicado: (2022)

Frataxin levels in peripheral tissue in Friedreich ataxia
por: Lazaropoulos, Michael, et al.
Publicado: (2015)

Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
por: Turchi, Riccardo, et al.
Publicado: (2020)

Correction: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
por: Turchi, Riccardo, et al.
Publicado: (2020)

Identification of Frataxin as a regulator of ferroptosis
por: Du, Jing, et al.
Publicado: (2020)

Ferredoxin Competes with Bacterial Frataxin in Binding to the Desulfurase IscS
por: Yan, Robert, et al.
Publicado: (2013)

Protein Stability and Dynamics Modulation: The Case of Human Frataxin
por: Roman, Ernesto A., et al.
Publicado: (2012)

Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism
por: Yoon, Heeyong, et al.
Publicado: (2015)

DNA methylation in Friedreich ataxia silences expression of frataxin isoform E
por: Rodden, Layne N., et al.
Publicado: (2022)

Chemical shift assignment of a thermophile frataxin
por: Rasheed, Masooma, et al.
Publicado: (2017)

c-MYC inhibition impairs hypoxia response in glioblastoma multiforme
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2016)

Evaluation of antibodies for western blot analysis of frataxin protein isoforms
por: Weng, Liwei, et al.
Publicado: (2019)

Structural and Functional Characterization of CreFH1, the Frataxin Homolog from Chlamydomonas reinhardtii
por: Terenzi, Agustina, et al.
Publicado: (2022)

Metal Ion Binding in Wild-Type and Mutated Frataxin: A Stability Study
por: Morante, S., et al.
Publicado: (2022)

Flavin Adenine Dinucleotide Rescues the Phenotype of Frataxin Deficiency
por: Gonzalez-Cabo, Pilar, et al.
Publicado: (2010)

The N-terminus of mature human frataxin is intrinsically unfolded
por: Prischi, Filippo, et al.
Publicado: (2009)

Turning Escherichia coli into a Frataxin-Dependent Organism
por: Roche, Béatrice, et al.
Publicado: (2015)

Activating frataxin expression by repeat-targeted nucleic acids
por: Li, Liande, et al.
Publicado: (2016)

Frataxins Emerge as New Players of the Intracellular Antioxidant Machinery
por: Uceda, Ana Belén, et al.
Publicado: (2021)

Modelling Protein Plasticity: The Example of Frataxin and Its Variants
por: Botticelli, Simone, et al.
Publicado: (2022)

Novel Frataxin Isoforms May Contribute to the Pathological Mechanism of Friedreich Ataxia
por: Xia, Haiyan, et al.
Publicado: (2012)

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly
por: Prischi, Filippo, et al.
Publicado: (2010)

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
por: Li, Kuanyu, et al.
Publicado: (2008)

Frataxin controls ketone body metabolism through regulation of OXCT1
por: Dong, Yi NA, et al.
Publicado: (2022)

Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia
por: Sahdeo, Sunil, et al.
Publicado: (2014)

Expression of Human Frataxin Is Regulated by Transcription Factors SRF and TFAP2
por: Li, Kuanyu, et al.
Publicado: (2010)

Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in Arabidopsis
por: Turowski, Valeria R., et al.
Publicado: (2015)

The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin()
por: Faraj, Santiago E., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jp3scmmtien02cv5m386iv4fo1