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Transient Suppression of Shigella flexneri Type 3 Secretion by a Protective O-Antigen-Specific Monoclonal IgA

Mucosal immunity to the enteric pathogen Shigella flexneri is mediated by secretory IgA (S-IgA) antibodies directed against the O-antigen (O-Ag) side chain of lipopolysaccharide. While secretory antibodies against the O-Ag are known to prevent bacterial invasion of the intestinal epithelium, the mec...

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Detalles Bibliográficos
Autores principales: Forbes, Stephen J., Bumpus, Tia, McCarthy, Elizabeth A., Corthésy, Blaise, Mantis, Nicholas J.
Formato: Texto
Lenguaje:English
Publicado: American Society of Microbiology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101778/
https://www.ncbi.nlm.nih.gov/pubmed/21610121
http://dx.doi.org/10.1128/mBio.00042-11